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Thionyl Chloride → 7-(Chlorophenylmethyl)quinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | alpha-Phenyl-7-quinolinemethanol | HCID 19967113 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 7-(Chlorophenylmethyl)quinoline | HCID 19967104 | 98.5% |
反応手順
A mixture of 3.2 parts of intermediate 2, namely α-phenyl-7-quinolinemethanol, 8 parts of thionyl chloride and 65 parts of dichloromethane was stirred for 4 hours at room temperature. The reaction mixture was evaporated and the residue was poured into water. The product was extracted with dichloromethane (3×39 parts) and the combined extracts were dried, filtered and evaporated, yielding 3.4 parts (98.5%) of 7-(chlorophenylmethyl)quinoline (interm. 23).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05441954 |
| 出典データセット | uspto-grants-1995_08 |
| ORD ID | ord-725cce31484f40b49f7cbd10520a71ab |
| 出典メモ | uspto-grants-1995_08 |