関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Chloride | HCID 312 | — |
| 反応物 | Oxalyl chloride | HCID 65578 | — |
| 反応物 | 1,3-Diphenyl-2-propyn-1-one | HCID 97637 | — |
| 反応物 | 1,3-Diphenyl-2-propyn-1-ol | HCID 296659 | — |
| 反応物 | Cornforth reagent | HCID 2724130 | — |
| 反応物 | Barium manganate | HCID 3084030 | — |
| 溶媒 | Dimethyl Sulfoxide | HCID 679 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Triethylamine | HCID 8471 | — |
| 生成物 | 1-Phenyl-3-[3-(4-(dimethylamino)benzyloxy)phenyl]-2-propyne-1-one | HCID 19388218 | — |
反応手順
In step b, the appropriate α-[(phenyl)ethynyl]-benzenemethanol compound of structure 6 can be oxidized to the corresponding 1-phenyl-3-phenyl-2-propyne-1-one compound of structure 5 by techniques and procedures well known and appreciated by one of ordinary skill in the art. For example, the appropriate α-[(phenyl)ethynyl]-benzenemethanol compound of structure 6 can be oxidized to the corresponding 1-phenyl-3-phenyl-2-propyne-1-one compound of structure 5 by means of either a Swern oxidation (dimethylsulfoxide, oxalyl chloride, and triethylamine), by means of pyridinium dichromate oxidation in a suitable aprotic solvent, such as methylene chloride or by means of barium manganate oxidation in a suitable aprotic solvent, such asmethylene chloride.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05446068 |
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| 出典データセット | uspto-grants-1995_08 |
|---|
| ORD ID | ord-33804668c08843c799ea85a43fce2d24 |
|---|
| 出典メモ | uspto-grants-1995_08 |
|---|
