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Nitric Acid → 6-fluoro-5-nitro-2(3H)-benzothiazolone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Nitric Acid | HCID 944 | — |
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | 2-Benzothiazolinone, 6-fluoro- | HCID 44667 | — |
| 生成物 | 6-fluoro-5-nitro-2(3H)-benzothiazolone | HCID 13957955 | — |
反応手順
Explaining the above conversion, 6-fluoro-2(3H)-benzothiazolone (V) [G. Mazzone et al: Farmaco, Ed. Sc., 32, (5), 348 (1977)] is reacted with a nitrating agent such as a mixture of sulfuric acid and nitric acid to give 6-fluoro-5-nitro-2(3H)-benzothiazolone (VI). The reaction is accomplished at a temperature of -10° to 10° C. instantaneously or within 5 hours. Sulfuric acid and nitric acid are respectively used in amounts of one equivalent to an excess amount and of 1 to 1.2 equivalents to the compound (V).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04828605 |
| 出典データセット | uspto-grants-1989_05 |
| ORD ID | ord-15bfc09a43274776a545a16ec9209664 |
| 出典メモ | uspto-grants-1989_05 |