化工社化工社 化学情報印刷レポート · 研究参考用
2-Methylimidazole → Estazolam
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Methylimidazole | HCID 12749 | — |
| 反応物 | Methanimidamide, hydrochloride (1:1) | HCID 10313058 | — |
| 反応物 | 7-Chloro-2-hydrazinyl-5-phenyl-3H-1,4-benzodiazepine | HCID 12390874 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Estazolam | HCID 3261 | — |
反応手順
A mixture of 2.8 parts of 7-chloro-2-hydrazino-5-phenyl-3H-1,4-benzodiazepine, 2.4 parts of formamidine hydrochloride and 2.5 parts of 2-methylimidazole is fused at 160° C for 10 minutes. Water is added to the mixture, followed by extraction with methylene chloride. The methylene chloride layer is washed with water, dried over sodium sulfate and the solvent is evaporated, whereby 8-chloro-6-phenyl-4H-s-triazolo [4,3-a][1,4] benzodiazepine is yielded. Recrystallization from ethyl acetate yields colorless flakes melting at 226° C to 227° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04116956 |
| 出典データセット | uspto-grants-1978_09 |
| ORD ID | ord-2f9d688256f6492a8e3493b7ddfa1c2a |
| 出典メモ | uspto-grants-1978_09 |