化工社化工社 化学情報印刷レポート · 研究参考用
4-Fluoroaniline → 3-(4-Fluorophenyl)-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Fluoroaniline | HCID 9731 | — |
| 反応物 | Ethyl orthoformate | HCID 31214 | — |
| 反応物 | Methyl 3-amino-4-phenylthiophene-2-carboxylate | HCID 2759782 | — |
| 反応物 | 3,7-Diphenylthieno[3,2-d]pyrimidin-4(3H)-one | HCID 78324865 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 3-(4-Fluorophenyl)-7-phenylthieno[3,2-d]pyrimidin-4(3H)-one | HCID 78324868 | 64% |
反応手順
In the same manner as the synthesis of Compound 1, methyl 3-amino-4-phenylthiophene-2-carboxylate (76 mg, 0.33 mmol), triethyl orthoformate (0.66 ml), 4-fluoroaniline (0.058 mg, 0.61 mmol), and acetic acid (0.08 ml) were used to give 68.5 mg (0.021 mmol, 64% yield) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09260448B2 |
| 出典データセット | uspto-grants-2016_02 |
| ORD ID | ord-10db1d7af43940478c8929d70ad1d048 |
| 出典メモ | uspto-grants-2016_02 |