関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 2,6-Lutidine | HCID 7937 | — |
| 反応物 | tert-Butyldimethylsilyl trifluoromethanesulphonate | HCID 123564 | — |
| 反応物 | 5-Bromo-2-methyl-2-pentanol | HCID 15507999 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | (4-Bromo-1,1-dimethyl-butoxy)-tert-butyl-dimethyl-silane | HCID 18334755 | 80% |
反応手順
To a −50° C. cooled solution of alcohol 8 (3 g, 16.6 mmol) in anhydrous CH2Cl2 (50 mL) was added 2,6-lutidine (2.32 mL, 2.13 g, 19.89 mmol) followed by TBSOTf (4.57 mL, 5.26 g, 19.9 mmol). The solution was stirred at 0° C. for 15 min and water (10 mL) was added. The mixture was extracted with CH2Cl2 (3×40 mL), and combined organic phases were washed with 1N aqueous solution of NaOH (40 mL), dried (Na2SO4), filtered and concentrated. The residue was purified by silica gel column chromatography (1% ethyl acetate/hexane) to give 3.9 g (13.2 mmol, 80%) of 9. 1H NMR (400 MHz, CDCl3) δ: 0.07 (6H, s), 0.85 (9H, s), 1.21 (6H, s), 1.55 (2H, m), 1.95 (2H, m),3.41 (2H, t, J=6.8 Hz)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07741313B2 |
|---|
| 出典データセット | uspto-grants-2010_06 |
|---|
| ORD ID | ord-04991a9aab194453ab61a9149bcefd4c |
|---|
| 出典メモ | uspto-grants-2010_06 |
|---|
