2-Amino-4-methylpyridine → N-(4-Methyl-2-pyridyl)acetamide

HRID 1789792

反応式

HRID 1789792 の反応式
[NH2:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][N:3]=1.[CH2:9]([O:11]CC)[CH3:10]>C(OC(=O)C)(=O)C>[CH3:8][C:6]1[CH:5]=[CH:4][N:3]=[C:2]([NH:1][C:9](=[O:11])[CH3:10])[CH:7]=1

参加物

4

反応物 2

HCID 15332-Amino-4-methylpyridineHCID 3283Diethyl Ether

生成物 1

HCID 220485N-(4-Methyl-2-pyridyl)acetamide収率 95%

試薬・触媒・溶媒 1

HCID 7918Acetic Anhydride溶媒

実験手順

2-Amino4-methylpyridine (99.0 g, 91.5 mmol) in acetic anhydride (250 mL) was warmed to 70° C. for two h. The mixture was cooled to room temperature and diethyl ether (100 mL) added. The product crystallized as white needle crystals. Filtering and drying in vacuo afforded N-(4-methyl-pyridin-2-yl)-acetamide (130 g, 95%).

後処理

  1. customThe product crystallized as white needle crystals
  2. filtrationFiltering
  3. customdrying in vacuo

出典と根拠

ORDレコード
ord-4c91d3469d9e4eeeb3d52c80632ed8db
出典データセット
uspto-grants-2006_07
特許番号
US07071175B1

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