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4-Hydroxypyrimidine → N-(5-(2-Phenylethyl)pyrimidin-4-yl)-L-phenylalanine Isopropyl Ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Hydroxypyrimidine | HCID 20695 | — |
| 反応物 | 4-Chloro-5-iodopyrimidine | HCID 11230204 | — |
| 反応物 | propan-2-yl (2S)-2-amino-3-phenylpropanoate hydrochloride | HCID 15599949 | — |
| 生成物 | N-(5-(2-Phenylethyl)pyrimidin-4-yl)-L-phenylalanine Isopropyl Ester | HCID 10318179 | — |
| 生成物 | propan-2-yl (2S)-2-amino-3-phenylpropanoate hydrochloride | HCID 15599949 | — |
反応手順
L-Phenylalanine isopropyl ester hydrochloride was prepared by Method LLL. 4(3H)-Pyrimidinone (Aldrich) was sequentially converted via Methods N and O to 4-chloro-5-iodopyrimidine. L-Phenylalanine isopropyl ester hydrochloride and 4-chloro-5-iodopyrimidine were coupled via Method P and the coupled product sequentially converted via Methods OOO and X to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07741328B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-889fc714dc684d58a4be9bd442b37b95 |
| 出典メモ | uspto-grants-2010_06 |