Water → 5-Bromo-6-methoxy-2-methylthioquinoline

HRID 1825859

反応式

HRID 1825859 の反応式
[Br:1][C:2]1[C:11]([O:12][CH3:13])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([S:14]([CH3:17])(=O)=O)=[N:7]2.O>CN(C=O)C>[Br:1][C:2]1[C:11]([O:12][CH3:13])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([S:14][CH3:17])=[N:7]2

参加物

4

反応物 2

HCID 962WaterHCID 221397325-Bromo-2-methanesulfonyl-6-methoxy-quinoline

生成物 1

HCID 221396965-Bromo-6-methoxy-2-methylthioquinoline

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

The 5-bromo-2-methanesulfonyl-6-methoxy-quinoline was dissolved in 20 mL DMF and treated with 3 eq NaSCH3. After stirring 1 hour at room temperature the mixture was poured into water and extracted with ether. The crystalline product, 5-bromo-6-methoxy-2-methylsulfanyl-quinoline, was isolated in quantitative yield.

後処理

  1. additiontreated with 3 eq NaSCH3
  2. extractionextracted with ether

出典と根拠

ORDレコード
ord-0b7c09262ddf44c49e91fbe659baecaf
出典データセット
uspto-grants-2006_05
特許番号
US07049325B2

関連ノート

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