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Dicyclohexylcarbodiimide → 4-(5-Undecyl-pyrimidin-2-yl)phenyl 5-ethyl-furan-2-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 反応物 | 5-Ethylfuran-2-carboxylic acid | HCID 247392 | — |
| 反応物 | 4-(5-Undecylpyrimidin-2-yl)phenol | HCID 135619682 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-(5-Undecyl-pyrimidin-2-yl)phenyl 5-ethyl-furan-2-carboxylate | HCID 15514981 | — |
反応手順
4.9 g of 4-(5-undecyl-pyrimidin-2-yl)phenol, 1.4 g of 5-ethyl-2-furancarboxylic acid (prepared as described by Perry et al., Appl. Organomet. Chem. 10, 389–392 (1996) from furan-2-carboxylic acid; m.p. 90° C.) and 2.1 g of dicyclohexylcarbodiimide are stirred for 24 h in 50 ml of dichloromethane at room temperature. Filtration, removal of the dichloromethane by distillation, purification by chromatography (silica gel; dichloromethane/heptane) and recrystallization from acetonitrile affords the target compound as colorless crystals having the phase sequence X 80 (N62) I.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07052742B1 |
| 出典データセット | uspto-grants-2006_05 |
| ORD ID | ord-f8cd3871948e49d4b8c8754327fecc45 |
| 出典メモ | uspto-grants-2006_05 |