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Iodoethane → 2-Ethyl-2-adamantanol
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Iodoethane | HCID 6340 | — |
| 反応物 | 2-Adamantanol | HCID 64149 | — |
| 反応物 | Adamantanone | HCID 64151 | — |
| 反応物 | Magnesium | HCID 5462224 | — |
| 反応物 | HCID 178461634 | HCID 178461634 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-Ethyl-2-adamantanol | HCID 4401951 | — |
反応手順
To 5 mL of ether was added 3.7 g (0.15 gram atom) of magnesium. To the mixture was added dropwise a solution of ethyl iodide (30 g, 0.19 mol) in ether (30 mL). The solution of ethylmagnesium iodide thus prepared was added dropwise to a solution of 2-adamantanone (20 g, 0.13 mol) in tetrahydrofuran (100 ml), and the mixture was stirred at room temperature overnight. GC analysis indicated that reduction products, i.e., 2-adamantanol and 2-ethyl-2-adamantanol were formed in 75% and 25%, respectively.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06770777B2 |
| 出典データセット | uspto-grants-2004_08 |
| ORD ID | ord-49046d439a0b4ff3b66b3de2c2459af8 |
| 出典メモ | uspto-grants-2004_08 |