2-Amino-4-methylpyridine → N-(4-Methyl-2-pyridyl)acetamide

HRID 1860390

反応式

HRID 1860390 の反応式
[NH2:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][N:3]=1.[C:9](OC(=O)C)(=[O:11])[CH3:10]>C(O)(=O)C>[C:9]([NH:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][N:3]=1)(=[O:11])[CH3:10]

参加物

4

反応物 2

HCID 15332-Amino-4-methylpyridineHCID 7918Acetic Anhydride

生成物 1

HCID 220485N-(4-Methyl-2-pyridyl)acetamide

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To a solution of 2-amino-4-methylpyridine (20 g) in acetic acid (80 ml) was added acetic anhydride and the resulting solution was refluxed for 3 h. The solution was concentrated in vacuo and the solid obtained was triturated with about 50 ml of water and carefully neutralised with solid sodium bicarbonate. The solid was filtered, washed with water and dried under vacuum to give the crude title compound as a white solid (20 g).

後処理

  1. temperaturethe resulting solution was refluxed for 3 h
  2. concentrationThe solution was concentrated in vacuo
  3. customthe solid obtained
  4. customwas triturated with about 50 ml of water
  5. filtrationThe solid was filtered
  6. washwashed with water
  7. customdried under vacuum

出典と根拠

ORDレコード
ord-363bc9926a5c42c3a799942f32be0d9c
出典データセット
uspto-grants-2003_03
特許番号
US06531466B2

関連ノート

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