Diazomethane → 4-Nitro-7-cyclopropyl-5-fluoro-1-isobutyl-2-(2-diethylphosphono-5-furanyl)benzimidazole

HRID 1872512

反応式

[N+:1]([C:4]1[C:12]2[N:11]=[C:10]([C:13]3[O:17][C:16]([P:18]([O:23][CH2:24][CH3:25])([O:20][CH2:21][CH3:22])=[O:19])=[CH:15][CH:14]=3)[N:9]([CH2:26][CH:27]([CH3:29])[CH3:28])[C:8]=2[C:7]([CH:30]=[CH2:31])=[CH:6][C:5]=1[F:32])([O-:3])=[O:2].[N+](=[CH2:35])=[N-]>CCOCC.CC([O-])=O.CC([O-])=O.[Pd+2]>[N+:1]([C:4]1[C:12]2[N:11]=[C:10]([C:13]3[O:17][C:16]([P:18]([O:23][CH2:24][CH3:25])([O:20][CH2:21][CH3:22])=[O:19])=[CH:15][CH:14]=3)[N:9]([CH2:26][CH:27]([CH3:28])[CH3:29])[C:8]=2[C:7]([CH:30]2[CH2:35][CH2:31]2)=[CH:6][C:5]=1[F:32])([O-:3])=[O:2]

参加物

実験手順

To a suspension of 1.0 mmol of 4-nitro-7-vinyl-5-fluoro-1-isobutyl-2-(2-diethylphosphono-5-furanyl)benzimidazole and 0.1 mmol of Pd(OAc)2 in 8 mL of ether was added an ether solution of diazomethane (generated from 3.0 g of 1-methyl-3-nitro-1-nitrosoguanidine) at 0 ° C. After stirring at room temperature 20 h solvent was removed and the residue chromatographed to give 4-nitro-7-cyclopropyl-5-fluoro-1-isobutyl-2-(2-diethylphosphono-5-furanyl)benzimidazole.

後処理

customwas removed
customthe residue chromatographed

出典と根拠

ORDレコード: ord-87f75d51ad9c4ec3ba4704a2bbeedbdf
出典データセット: uspto-grants-2000_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06110903

反応式

参加物

反応物 2

生成物 1

試薬・触媒・溶媒 2

実験手順

後処理

出典と根拠

関連ノート