(Z)-2-Hydroxydoxepin → (E)-2-Hydroxy Doxepin

HRID 1894781

反応式

HRID 1894781 の反応式
[OH:1][C:2]1[CH:22]=[CH:21][C:5]2[O:6][CH2:7][C:8]3[CH:20]=[CH:19][CH:18]=[CH:17][C:9]=3/[C:10](=[CH:11]/[CH2:12][CH2:13][N:14]([CH3:16])[CH3:15])/[C:4]=2[CH:3]=1>Cl.CO>[OH:1][C:2]1[CH:22]=[CH:21][C:5]2[O:6][CH2:7][C:8]3[CH:20]=[CH:19][CH:18]=[CH:17][C:9]=3/[C:10](=[CH:11]\[CH2:12][CH2:13][N:14]([CH3:16])[CH3:15])/[C:4]=2[CH:3]=1

参加物

4

反応物 1

HCID 67319009(Z)-2-Hydroxydoxepin

生成物 1

HCID 59023617(E)-2-Hydroxy Doxepin

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 887Methanol溶媒

反応条件

温度
140 °C

実験手順

A mixture of (Z)-2-Hydroxy-11-(3-dimethylaminopropylidene)-6,11-dihydrodibenzo[b,e]oxepin (2.5 mg, 8.5×10−6 mol) was dissolved in a mixture of hydrochloric acid (1 mL) and methanol (9 mL) and heated at 140° C. (oil bath) for 4 hr. The product was isolated by means of HPLC and evaporation of solvents.

後処理

  1. customThe product was isolated by means of HPLC and evaporation of solvents

出典と根拠

ORDレコード
ord-d7316b5332224b23afe943ea57d90c92
出典データセット
uspto-grants-2013_08
特許番号
US08513299B2

関連ノート

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