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Sodium Hydroxide → N-(4,5-Dihydro-1H-imidazol-2-yl)-2-methyl-2H-indazol-4-amine monohydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 2-Chloro-4,5-dihydroimidazole | HCID 236236 | — |
| 反応物 | 2-Chloroimidazoline sulfate | HCID 12503398 | — |
| 反応物 | 2-Methyl-2H-indazol-4-amine | HCID 15413170 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | N-(4,5-Dihydro-1H-imidazol-2-yl)-2-methyl-2H-indazol-4-amine monohydrochloride | HCID 121924 | — |
反応手順
4 g 4-amino-2-methyl-indazole is dissolved in 120 ml THF. The solution is treated with a solution of 2-chloro-imidazoline base, which is prepared from 10 g 2-chloro-imidazoline sulfate (prepared according to J. Heteroc. Chem. 11, 258) with 2 n NaOH in methylene chloride.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04436913 |
| 出典データセット | uspto-grants-1984_03 |
| ORD ID | ord-da576370875c43da9bcb668ba62b50f3 |
| 出典メモ | uspto-grants-1984_03 |