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Potassium Carbonate → 4-(2-(4-bromophenylamino)benzo[d]thiazol-5-yloxy)-N-methylpicolinamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 4-Chloro-N-methylpicolinamide | HCID 1476814 | — |
| 反応物 | Potassium bis(trimethylsilyl)amide | HCID 3251421 | — |
| 反応物 | 2-[(4-Bromophenyl)amino]benzothiazol-5-ol | HCID 22040876 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-(2-(4-bromophenylamino)benzo[d]thiazol-5-yloxy)-N-methylpicolinamide | HCID 21037245 | — |
反応手順
The mixture containing 2-[(4-bromophenyl)amino]benzothiazol-5-ol (1 eq), Potassiumbis(trimethylsilyl)amide (4 eq), was stirred in dimethylformamide for 30 min at room temperature. To this mixture was added (4-chloro(2-pyridyl)-N-methylcarboxamide (1 eq) and Potassium carbonate (1.2 eq) and microwaved for 6 mins at 150° C. The reaction mixture was then concentrated and partitioned between ethyl acetate and water. The organic layer was separated and washed with brine, dried, filtered and concentrated. Purification on Prep LC yielded the desired product. MS: MH+=455
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08614330B2 |
| 出典データセット | uspto-grants-2013_12 |
| ORD ID | ord-d83015752b0f4ccaa9e811bd117c5b61 |
| 出典メモ | uspto-grants-2013_12 |