関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Formic Acid | HCID 284 | — |
| 反応物 | Ethylamine | HCID 6341 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Acetylacetone | HCID 31261 | — |
| 反応物 | 5-Methyl hydrogen L-glutamate | HCID 68662 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | L-Theanine | HCID 439378 | 82% |
反応手順
First, 20.0 g (0.124 mol) of L-glutamic acid-γ-methyl ester was suspended in 20 g of methanol. To this, 13.7 g (0.137 mol) of acetylacetone and 12.5 g (0.124 mol) of triethylamine were added. The mixture was stirred at 60° C. for one hour. Subsequently, 80 g (1.24 mol) of 70% ethylamine was added to the mixture. After the mixture was allowed to react for 6 hours, excessive ethylamine was distilled away under reduced pressure. To this, 11.4 g (0.246 mol) of formic acid and 120 mL of 2-propanol (IPA) were added. The crystal precipitated was filtrated by suction and washed with 20 mL of IPA to obtain wet matter. The wet matter was dried under reduced pressure to obtain 17.7 g of theanine as a white crystal substance (yield: 82%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08178722B2 |
|---|
| 出典データセット | uspto-grants-2012_05 |
|---|
| ORD ID | ord-a804b629c46443cbad14b550f62e952b |
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| 出典メモ | uspto-grants-2012_05 |
|---|
