Bromine → 2-bromo-1-(3-nitrophenyl)propan-1-one

HRID 1942990

反応式

HRID 1942990 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]([C:10](=[O:13])[CH2:11][CH3:12])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].[Br:14]Br>C(O)(=O)C>[Br:14][CH:11]([CH3:12])[C:10]([C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1)=[O:13]

参加物

4

反応物 2

HCID 24408BromineHCID 870963'-Nitropropiophenone

生成物 1

HCID 102644672-bromo-1-(3-nitrophenyl)propan-1-one

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

To a stirred solution of 1-(3-nitrophenyl)propan-1-one (1.41 g, 7.90 mmol) in acetic acid (20 mL) was added bromine dropwise (1.27 g, 7.93 mmol) and the mixture was stirred at room temperature for 24 h. The mixture was poured into ice-cold water and the organic layer was extracted with DCM. The organic extract was washed with sat. aq. NaHCO3 and brine, dried over anhydrous MgSO4, and filtered. Evaporation of the solvent under reduced pressure afforded 11z as a white solid which was used in the next step without further purification (1.78 g, 87%). 1H NMR matches literature data.

後処理

  1. additionThe mixture was poured into ice-cold water
  2. extractionthe organic layer was extracted with DCM
  3. extractionThe organic extract
  4. washwas washed with sat. aq. NaHCO3 and brine
  5. dry with materialdried over anhydrous MgSO4
  6. filtrationfiltered
  7. customEvaporation of the solvent under reduced pressure

出典と根拠

ORDレコード
ord-244e704eab064c4daa8d3aa73bb770ea
出典データセット
uspto-grants-2013_03
特許番号
US08389736B2

関連ノート

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