Ethanone, 2-chloro-1,2-diphenyl- → (RS)-7-(2-Oxo-1,2-diphenyl-ethyl)-1-phenyl-1,7-diaza-spiro[3.5]nonan-2-one

関与物質

反応手順

A suspension of 2-chloro-1,2-diphenyl-ethanone (0.23 g, 1 mmol), 1-phenyl-1,7-diazaspiro[3.5]nonan-2-one (0.2 g, 0.9 mmol) and sodium bicarbonate (0.23 g) in 2-butanone was boiled for 4 h with stirring. The mixture was cooled, the solvent was removed in vacuo and the residue was purified by chromatography on silica gel with ethylacetate/hexane (1:2) to yield 0.33 g (87%) of the title compound. MS: m/e=411.3 (M+H+).

情報源と証拠