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HRID 19608作成日：2026年10月23日
tert-Butyl (4-aminophenyl)carbamate → {4-[5-(6-Benzyloxy-naphthalen-2-yl)-pyrazolo[1,5-c]pyrimidin-7-ylamino]-phenyl}-carbamic acid tert-butyl ester
https://huagongshe.com/ja/reaction/19608
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | tert-Butyl (4-aminophenyl)carbamate | HCID 688611 | — |
| 反応物 | 5-(6-Benzyloxy-naphthalen-2-yl)-7-methanesulfonyl-pyrazolo[1,5-c]pyrimidine | HCID 67319776 | — |
| 生成物 | {4-[5-(6-Benzyloxy-naphthalen-2-yl)-pyrazolo[1,5-c]pyrimidin-7-ylamino]-phenyl}-carbamic acid tert-butyl ester | HCID 67319245 | 46% |
反応手順
A mixture of 5-(6-benzyloxy-naphthalen-2-yl)-7-methanesulfonyl-pyrazolo[1,5-c]pyrimidine (compound D2)(87 mg) and 4-amino-phenyl-carbamic acid tert-butyl ester (208 mg) is heated neat at 130 to 140° C. bath temperature for 20 min. After cooling, the crude product is purified by silica gel flash chromatography. A nearly colorless solid (51 mg, 46%) with melting temperature of 189° C. is obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US07745446B2 |
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| 出典データセット | uspto-grants-2010_06 |
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| ORD ID | ord-511010926b6f4983a5ba276bd9effa2d |
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| 出典メモ | uspto-grants-2010_06 |
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