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tert-butyl N-[(3S)-piperidin-3-yl]carbamate → Hydrochloric Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | tert-butyl N-[(3S)-piperidin-3-yl]carbamate | HCID 1514171 | — |
| 反応物 | 4-Chloroisoquinoline-5-sulfonyl chloride | HCID 22121908 | — |
| 生成物 | Hydrochloric Acid | HCID 313 | 1,932.7% |
| 生成物 | (S)-3-(tert-Butoxycarbonylamino)-1-(4-chloro-5-isoquinolinesulfonyl)piperidine | HCID 67243279 | — |
| 生成物 | (S)-3-Amino-1-(4-chloro-5-isoquinolinesulfonyl)piperidine | HCID 67244043 | — |
反応手順
(S)-3-(tert-Butoxycarbonylamino)-1-(4-chloro-5-isoquinolinesulfonyl)-piperidine (Intermediate 18a) was prepared from 4-chloro-5-isoquinolinesulfonyl chloride (183 mg) and (S)-3-(tert-butoxycarbonylamino)piperidine (168 mg) according to the method described in Example 1-1, Step A, and then used in the method of Example 1-1, Step B in a similar manner to obtain the title compound as hydrochloride (164 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08415372B2 |
| 出典データセット | uspto-grants-2013_04 |
| ORD ID | ord-66e2bd0e5d04453c84eade2bb4c82cdb |
| 出典メモ | uspto-grants-2013_04 |