化工社化工社 化学情報印刷レポート · 研究参考用
2,3-Dihydroxybutanedioic Acid → Ritanserin
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,3-Dihydroxybutanedioic Acid | HCID 875 | — |
| 反応物 | Ritanserin | HCID 5074 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | Ritanserin | HCID 5074 | 98% |
| 生成物 | 2,3-Dihydroxybutanedioate | HCID 3806114 | — |
反応手順
A mixture of 4 parts of 6-[2-[4-[bis(4-fluorophenyl)-methylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]-pyrimidin-5-one, 1.3 parts of (+)-[R-(R*,R*)]-2,3-dihydroxybutanedioic acid and 96 parts of 2-propanol was stirred and heated till all solid entered solution. The whole was cooled while stirring. The product was filtered off and dried, yielding 5.1 parts (98%) of (+)-6-[2-[4-[bis(4-fluorophenyl)methylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one [R-(R*,R*)]-2,3-dihydroxybutanedioate(1:1).; mp. 198.7° C. (compound 147).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04485107 |
| 出典データセット | uspto-grants-1984_11 |
| ORD ID | ord-44e9fbaec7d64f349d1ea253b0c88813 |
| 出典メモ | uspto-grants-1984_11 |