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tert-Butyl 4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate → tert-Butyl 4-(1-hydroxy-3-methoxy-3-oxo-1-(4-pivalamidopyridin-3-yl)propan-2-yl)piperidine-1-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | tert-Butyl 4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate | HCID 1514280 | — |
| 反応物 | tert-Butyl 4-(1-hydroxy-3-methoxy-3-oxo-1-(2-pivalamidopyridin-3-yl)propan-2-yl)piperidine-1-carboxylate | HCID 59731884 | — |
| 反応物 | 3-Formyl-4-pyridinyl-2,2-dimethylpropanamide | HCID 86604792 | — |
| 生成物 | tert-Butyl 4-(1-hydroxy-3-methoxy-3-oxo-1-(4-pivalamidopyridin-3-yl)propan-2-yl)piperidine-1-carboxylate | HCID 59732007 | 54% |
反応手順
tert-butyl 4-(2-methoxy-2-oxoethyl)piperidine-1-carboxylate (1.33 g, 5.2 mmol) and N-(3-formyl-4-pyridinyl-2,2-dimethylpropanamide (1.0 g, 4.7 mmol) were reacted in a manner analogous to the preparation of tert-butyl 4-(1-hydroxy-3-methoxy-3-oxo-1-(2-pivalamidopyridin-3-yl)propan-2-yl)piperidine-1-carboxylate. Title compound was obtained as white foam in 54% yield. (M+H)+=464.2.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07544680B2 |
| 出典データセット | uspto-grants-2009_06 |
| ORD ID | ord-ae8b8b5874c2478385047b76e41aa43c |
| 出典メモ | uspto-grants-2009_06 |