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Ammonia → 2-Amino-2-iminoethylcarbamate AcOH
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | N-Acetyl-L-Cysteine | HCID 12035 | — |
| 反応物 | tert-butyl N-(cyanomethyl)carbamate | HCID 545844 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 2-Amino-2-iminoethylcarbamate AcOH | HCID 131727841 | 62.6% |
反応手順
N-Boc-aminoacetonitrile (40.2 g, 257.4 mmol) and N-acetylcysteine (42.0 g, 257.4 mmol) were dissolved in methanol (300 mL) at 60° C. and ammonia was passed through for 18 h. The solvent was removed in vacuo. After ion exchange chromatography (Amberlite IRA-400 (AcOH)) and recrystallisation from acetone, 28.4 g (53%) of the sub-title compound was obtained as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07645751B2 |
| 出典データセット | uspto-grants-2010_01 |
| ORD ID | ord-7cb4b35b7c9f42a59a85e231a3293f05 |
| 出典メモ | uspto-grants-2010_01 |