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1-(1,1-dimethylethyl)-N-(phenylmethyl)-4-Piperidinamine → 1-tert-Butylpiperidin-4-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(1,1-dimethylethyl)-N-(phenylmethyl)-4-Piperidinamine | HCID 22647939 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 1-tert-Butylpiperidin-4-amine | HCID 17750401 | 64.7% |
反応手順
A solution of N-benzyl-1-tert-butylpiperidin-4-amine (1.56 g) and 10% palladium on carbon (2 g) in MeOH (250 ml) was hydrogenated in a Parr shaker at 50 psi for 16 hours. The solution was filtered and the reaction mixture reduced in vacuo, to yield 1-tert-butylpiperidin-4-amine (0.64 g) (LC/MS: Rt 02.31, no [M+H]+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745638B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-5abc4cfd8fc54361a1e7c5a7b32fbdbd |
| 出典メモ | uspto-grants-2010_06 |