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Potassium Carbonate → [1-(1,3-Dibutylxanthin-7-yl)methyl]dimethylphosphine Oxide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Phosphine oxide, (chloromethyl)dimethyl- | HCID 74224 | — |
| 反応物 | 1,3-Dibutylxanthine | HCID 101421 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | [1-(1,3-Dibutylxanthin-7-yl)methyl]dimethylphosphine Oxide | HCID 19689263 | — |
反応手順
5 g (0.01 9 mol) of 1,3-dibutylxanthine were stirred at 80° C. for 6 hours with 2.88 g (0.0228 mol) of chloromethyldimethylphosphine oxide and 3.2 g (0.0228 mol) of potassium carbonate in 80 ml of DMF. The solution was cooled to room temperature and filtered, and the filtrate was concentrated under reduced pressure. The residue which remained was crystallized in petroleum ether/ethyl acetate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05728686 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-20ece88fc4e64225b2c8a9f117afb490 |
| 出典メモ | uspto-grants-1998_03 |