関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Formaldehyde | HCID 712 | — |
| 反応物 | Dimethylamine, hydrochloride | HCID 10473 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 2,5-Dimethylpyrazine | HCID 31252 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-(beta-Dimethylaminoethyl)-5-methylpyrazine | HCID 20377611 | 34.6% |
反応手順
A mixture of 75.0 g (0.7 mole) of 2,5-dimethylpyrazine and 41.0 g (0.5 mole) of dimethylamine hydrochloride was heated at 140° C. 60.0 g (38% aqueous solution) (0.75 mole) of formaldehyde was added over a period of two hours. After two hours additional heating the mixture was cooled. It was diluted with 110 ml of water, made basic with 10% sodium hydroxide and extracted with chloroform. The solvent was removed and the residue distilled to give 28.6 g of 2-(β-dimethylaminoethyl)-5-methylpyrazine, b.p. 106°-110° C. at 10 mm Hg.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04183933 |
|---|
| 出典データセット | uspto-grants-1980_01 |
|---|
| ORD ID | ord-8e7c5d9d62e44642ad0dfac211e1259f |
|---|
| 出典メモ | uspto-grants-1980_01 |
|---|
