関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | 2-(2,6-Dichloro-phenyl)-N-(4,6-dichloro-pyrimidin-5-yl)-acetamide | HCID 57742462 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 7-Chloro-2-(2,6-dichlorobenzyl)oxazolo[5,4-d]pyrimidine | HCID 57742456 | 61.1% |
反応手順
To a solution of 2-(2,6-dichloro-phenyl)-N-(4,6-dichloro-pyrimidin-5-yl)-acetamide (183 mg, 0.52 mmol) in CH3CN (3 mL) was added Cs2CO3 (342 mg, 1.1 mmol). The resulting mixture was heated to 60° C. in a sealed tube. After 2 h, the reaction mixture was cooled and concentrated. The residue was purified by FCC to afford a colorless solid (100 mg, 61%). MS (ESI): mass calcd. for C12H6Cl3N3O, 312.9; m/z found, 313.9 [M+H]+. 1H NMR (CD3OD): 8.69 (s, 1H), 7.43 (d, J=8.0 Hz, 2H), 7.33-7.28 (m, 1H), 4.72 (s, 2H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08288397B2 |
|---|
| 出典データセット | uspto-grants-2012_10 |
|---|
| ORD ID | ord-4052de909c85420fb10d505a90343704 |
|---|
| 出典メモ | uspto-grants-2012_10 |
|---|
