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2-Methyl-2H-indazole-3-carboxylic acid → 2-methyl-2H-indazole-3-carboxylic acid {(1S,3S,5S)-2-[2-amino-5-(3-fluoro-phenyl)-thiazole-4-carbonyl]-2-aza-bicyclo[3.1.0]hex-3-ylmethyl}-amide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Methyl-2H-indazole-3-carboxylic acid | HCID 7060537 | — |
| 反応物 | [2-amino-5-(3-fluoro-phenyl)-thiazol-4-yl]-((1S,3S,5S)-3-aminomethyl-2-aza-bicyclo[3.1.0]hex-2-yl)-methanone | HCID 86653658 | — |
| 生成物 | 2-methyl-2H-indazole-3-carboxylic acid {(1S,3S,5S)-2-[2-amino-5-(3-fluoro-phenyl)-thiazole-4-carbonyl]-2-aza-bicyclo[3.1.0]hex-3-ylmethyl}-amide | HCID 86653679 | — |
反応手順
prepared by reaction of [2-amino-5-(3-fluoro-phenyl)-thiazol-4-yl]-((1S,3S,5S)-3-aminomethyl-2-aza-bicyclo[3.1.0]hex-2-yl)-methanone with 2-methyl-2H-indazole-3-carboxylic acid. LC-MS (basic): tR=0.80 min; [M+H]+=491.0.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08288435B2 |
| 出典データセット | uspto-grants-2012_10 |
| ORD ID | ord-09a5d45716be49779dade6d9c08b3d99 |
| 出典メモ | uspto-grants-2012_10 |