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Ethyl 7-bromoheptanoate → 7-(4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2-oxo-2H-chromen-8-yloxy)heptanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl 7-bromoheptanoate | HCID 122490 | — |
| 反応物 | 4-(3,5-dichloropyridin-4-ylamino)-8-hydroxy-7-methoxy-2H-chromen-2-one | HCID 24849570 | — |
| 生成物 | 7-(4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2-oxo-2H-chromen-8-yloxy)heptanoic acid | HCID 24849846 | — |
反応手順
The title compound was prepared from ethyl 7-bromoheptanoate and 4-(3,5-dichloropyridin-4-ylamino)-8-hydroxy-7-methoxy-2H-chromen-2-one (Example 29) following the procedures outlined in Examples 25 & 42. 1H NMR (400 MHz, DMSO-d6): δ 9.50 (s, 1H), 8.81 (s, 2H), 7.94 (d, 1H), 7.19 (d, 1H), 4.63 (s, 1H), 3.97 (t, 2H), 3.91 (s, 3H), 2.19 (t, 2H), 1.66 (m, 2H), 1.54-1.40 (m, 4H), 1.31 (m, 2H); MS (ESI): 480.9.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745646B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-ef71073614044396962468d2b7f9759d |
| 出典メモ | uspto-grants-2010_06 |