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Hydrochloric Acid → 4-(1-Naphthyl)-4-oxobutanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Naphthalene | HCID 931 | — |
| 反応物 | Succinic anhydride | HCID 7922 | — |
| 反応物 | Aluminum(III) Chloride | HCID 6451240 | — |
| 溶媒 | Nitrobenzene | HCID 7416 | — |
| 生成物 | 4-(1-Naphthyl)-4-oxobutanoic acid | HCID 277786 | — |
反応手順
A mixture of naphthalene (40 g) and succinic anhydride (20 g) was added to a well stirred suspension of aluminum trichloride (55 g) in nitrobenzene (140 ml). The resulting mixture was stirred overnight at room temperature. The mixture was then poured slowly onto ice-water (600 g) and acidified with 6N-hydrochloric acid. The crude acid was filtered, washed with water until washings were neutral and recrystallized from ethanol yielding the product (m.p. 170°-172° C.).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05728694 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-3230ec97664440b59969f4a912460e21 |
| 出典メモ | uspto-grants-1998_03 |