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Dipropylamine → 3-(Dipropylcarbamoyl)benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dipropylamine | HCID 8902 | — |
| 反応物 | Benzoic acid, 3-((dipropylamino)carbonyl)-, methyl ester | HCID 182776 | — |
| 反応物 | 3-(Methoxycarbonyl)benzoic acid | HCID 601880 | — |
| 反応物 | N-Boc-cis-4-hydroxy-D-proline | HCID 688616 | — |
| 反応物 | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 3-(Dipropylcarbamoyl)benzoic acid | HCID 182769 | — |
反応手順
Step E (1): Methyl 3-(dipropylcarbamoyl)benzoate. To a solution of 3-(methoxycarbonyl)benzoic acid (6.7 g, 37.2 mmol) in DMF (60 mL) was added HATU (17.0 g, 44.7 mmol) and dipropylamine (9.4 g, 93 mmol) and the reaction mixture was stirred at rt overnight. Ethyl acetate (600 mL) was added and the mixture was washed with H2O, dried and concentrated to give the title compound was used in the next step without purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745470B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-b9ee9195d30b401ea3470495f37b483c |
| 出典メモ | uspto-grants-2010_06 |