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Dimethylformamide → 4-Chloro-4'-methylsulfonylmethylbenzophenone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Sodium methanesulfinate | HCID 2733271 | — |
| 反応物 | 4-(4-Chlorobenzoyl)benzyl bromide | HCID 9839651 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-Chloro-4'-methylsulfonylmethylbenzophenone | HCID 18779913 | 90.6% |
反応手順
4-bromomethyl-4'-chlorobenzophenone (3.1 g) and sodium methanesulfinate (1.5 g) were added to N,N-dimethylformamide (50 ml), and the mixture was stirred for 16 hours at room temperature. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with water and dried over anhydrous magnesium sulfate. Ethyl acetate was distilled off under reduced pressure. The residual solid was washed with n-hexane to obtain the desired product (2.8 g, melting point: 164° to 166° C., yield: 90%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05728699 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-ade4f0eddda041248b4ac3c87079d5f2 |
| 出典メモ | uspto-grants-1998_03 |