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3,5-Heptanedione, 2,6-dimethyl- → 1-(6-Bromo-2-isopropyl-4-phenyl-quinolin-3-yl)-2-methyl-propan-1-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3,5-Heptanedione, 2,6-dimethyl- | HCID 87597 | — |
| 反応物 | 2-Amino-5-bromobenzophenone | HCID 99677 | — |
| 生成物 | 1-(6-Bromo-2-isopropyl-4-phenyl-quinolin-3-yl)-2-methyl-propan-1-one | HCID 11646911 | 46% |
反応手順
The title compound was prepared from (2-Amino-5-bromo-phenyl)-phenyl-methanone [example A16] and 2,6-dimethyl-3,5-heptanedione according to the method of example 1, except that the reaction time was of 96 h and the residue was purified by chromatography on aminated silica gel with heptane/ethyl acetate (85:15). Yield: 46%. MS: m/z=395/397 (M).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07576217B2 |
| 出典データセット | uspto-grants-2009_08 |
| ORD ID | ord-49e363229f974074ba119d98229ce7cd |
| 出典メモ | uspto-grants-2009_08 |