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3-Acetylpyridine → 5-(Pyridin-3-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Acetylpyridine | HCID 9589 | — |
| 反応物 | 1,3-Butanedione, 4,4,4-trifluoro-1-(3-pyridinyl)- | HCID 68495 | — |
| 反応物 | HCID 178510443 | HCID 178510443 | — |
| 生成物 | 5-(Pyridin-3-yl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile | HCID 46949670 | 16% |
反応手順
Reaction of 1-pyridin-3-yl-4,4,4-trifluoro-butane-1,3-dione (217 mg, 1.0 mmol), prepared from commercially available 3-acetylpyridine according to general procedure A, and 3-amino-4-cyano-pyrazole (108 mg, 1.0 mmol) according to general procedure B yielded the title compound as an off-white solid (45 mg, 16%). MS (ISP) 290.2 [(M+H)+]; mp 193° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07514443B2 |
| 出典データセット | uspto-grants-2009_04 |
| ORD ID | ord-9ee1b95215684ea1905bf436f94e9a47 |
| 出典メモ | uspto-grants-2009_04 |