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Triethylamine → 3-chloro-4-fluoro-N-(1-methyl-1-phenylethyl)benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Cumylamine | HCID 68509 | — |
| 反応物 | 3-Chloro-4-fluorobenzoyl Chloride | HCID 2736548 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 3-chloro-4-fluoro-N-(1-methyl-1-phenylethyl)benzamide | HCID 68491942 | 97.1% |
反応手順
In a similar manner to Step 1 of Example 16, 3-chloro-4-fluorobenzoyl chloride (3.00 g, 15.5 mmol) was dissolved in dichloromethane (60 mL), and the solution was treated with cumylamine (2.45 mL, 17.1 mmol), triethylamine (3.24 mL, 23.3 mmol) and DMAP (189 mg, 1.05 mmol), followed by purification by slurry using diisopropylether to obtain 3-chloro-4-fluoro-N-(1-methyl-1-phenylethyl)benzamide (4.39 g, yield 97%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745641B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-ffb7690b8cdc47748458e2379a0e394f |
| 出典メモ | uspto-grants-2010_06 |