化工社化工社 化学情報印刷レポート · 研究参考用
Aluminium lithium hydride → 3-Methyl-5-(1-methyl-2(S)-pyrrolidinyl)isoxazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Aluminium lithium hydride | HCID 21226445 | — |
| 反応物 | 1-(1-CBZ-2(S)-pyrrolidinyl)-1-buten-3-one oxime | HCID 86748737 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 3-Methyl-5-(1-methyl-2(S)-pyrrolidinyl)isoxazole | HCID 119380 | — |
反応手順
The Cbz-protected compound of step 23d is reacted with LAH in THF at 0° C. as described in Example 24 below, and the title compound is isolated in pure form by extraction with ethyl acetate and distillation under high vacuum.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05424444 |
| 出典データセット | uspto-grants-1995_06 |
| ORD ID | ord-daec843a89594a82897f91c6ed9e178d |
| 出典メモ | uspto-grants-1995_06 |