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Water → 1-Dimethylsulfamoyl-2-ethylimidazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2-Ethylimidazole | HCID 66130 | — |
| 反応物 | Dimethylsulphamoyl chloride | HCID 83372 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 1-Dimethylsulfamoyl-2-ethylimidazole | HCID 23293183 | 86.1% |
反応手順
To a stirred solution of 2-ethylimidazole (100 g) and triethylamine (115 g) in chloroform (800 ml) at 0° C. is added a solution of dimethylsulfamoyl chloride (153 g) in chloroform (200 ml). The mixture is stirred overnight at room temperature. Water (1.5 liter) is added to the reaction mixture after which the organic layer is separated and concentrated. The residue is dissolved in ethyl acetate (1 liter) and washed with water, and then dried over sodium sulfate and concentrated. Distillation gives 1-dimethylsulfamoyl-2-ethylimidazole (182 g) as a colorless liquid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05424316 |
| 出典データセット | uspto-grants-1995_06 |
| ORD ID | ord-61bc5d6024df4362ad3eac19e9288450 |
| 出典メモ | uspto-grants-1995_06 |