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Picolinic acid → Diethyl 2-(5-bromopyridin-2-yl)malonate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Picolinic acid | HCID 1018 | — |
| 反応物 | Diethyl Malonate | HCID 7761 | — |
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | 5-Bromo-2-iodopyridine | HCID 593690 | — |
| 触媒 | Copper | HCID 23978 | — |
| 触媒 | Copper iodide | HCID 83717 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | Diethyl 2-(5-bromopyridin-2-yl)malonate | HCID 59238270 | — |
反応手順
2-(5-Bromo-pyridin-2-yl)-malonic acid diethyl ester (XXXVI) is prepared by copper-catalyzed reaction with malonic acid diethyl ester. The reaction is typically performed by mixing XXXV with malonic acid diethyl ester, copper iodide, cesium carbonate, and pyridine-2-carboxylic acid in 1,4-dioxane and heating to 70 degrees Celsius for 24 hours under nitrogen atmosphere.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08202866B2 |
| 出典データセット | uspto-grants-2012_06 |
| ORD ID | ord-4a0d2e13f2e54af8857cd02a2ed3add9 |
| 出典メモ | uspto-grants-2012_06 |