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Formic Acid → tert-Butyl [(2-chlorophenyl)(phenylsulphonyl)methyl]carbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Formic Acid | HCID 284 | — |
| 反応物 | 2-Chlorobenzaldehyde | HCID 6996 | — |
| 反応物 | tert-Butyl carbamate | HCID 77922 | — |
| 反応物 | Benzenesulfinic acid, sodium salt | HCID 2723840 | — |
| 溶媒 | Methanol--water (1/1) | HCID 22242641 | — |
| 生成物 | tert-Butyl [(2-chlorophenyl)(phenylsulphonyl)methyl]carbamate | HCID 59536806 | — |
反応手順
Quantities of 2.78 g (23.7 mmol) of tert-butyl carbamate and 7.79 g (47.4 mmol) of benzenesulphinic acid sodium salt were introduced in 55 ml of methanol/water 1:2 at RT and admixed with 5 g (35.6 mmol) of 2-chlorobenzaldehyde and then with 1.78 ml (47.1 mmol) of formic acid. The mixture was stirred at RT for 2 days. The white solid precipitated was filtered off with suction and washed in succession twice each with water and diethyl ether. Drying in an HV gave 5.77 g (42% of theory) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08202895B2 |
| 出典データセット | uspto-grants-2012_06 |
| ORD ID | ord-e17fb02282f34901aeb55b4f32a4045b |
| 出典メモ | uspto-grants-2012_06 |