化工社化工社 化学情報印刷レポート · 研究参考用
Potassium Hydroxide → 3-[(4-Fluorophenyl)thio]-2-hydroxy-2-methylpropanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | 4-Fluorothiophenol | HCID 67789 | — |
| 反応物 | Methyl 2-hydroxy-2-methyl-3-(4-fluorophenylthio)-propionate | HCID 21966928 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3-[(4-Fluorophenyl)thio]-2-hydroxy-2-methylpropanoic acid | HCID 9813367 | — |
反応手順
The methyl 2-methyl-oxirane-carboxylate of formula (1), which was obtained by epoxidation, was reacted with 4-fluorothiophenol [formula (2)] in the presence of sodium hydride under the conditions listed in Scheme-2. The obtained methyl 2-hydroxy-2-methyl-3-(4-fluorophenylthio)-propionate of formula (3) was hydrolyzed with potassium hydroxide in aqueous ethanol over a period of 22 hours to yield the 2-hydroxy-2-methyl-3-(4-fluorophenylthio)-propionic acid of formula (4), which was converted into acid chloride of formula (5) with thionyl chloride in dimethyl acetamide at −15° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07102026B2 |
| 出典データセット | uspto-grants-2006_09 |
| ORD ID | ord-c604cc732ca64c99b9765e91bfb0a4be |
| 出典メモ | uspto-grants-2006_09 |