Acetic Anhydride → N-(4-Bromo-2-methylphenyl)acetamide

HRID 2216249

反応式

HRID 2216249 の反応式
C(O[C:5](=[O:7])[CH3:6])(=O)C.[Br:8][C:9]1[CH:15]=[CH:14][C:12]([NH2:13])=[C:11]([CH3:16])[CH:10]=1.C([O-])(=O)C.[Na+]>C1(C)C=CC=CC=1.C(OCC)(=O)C>[CH3:16][C:11]1[CH:10]=[C:9]([Br:8])[CH:15]=[CH:14][C:12]=1[NH:13][C:5]([CH3:6])=[O:7]

参加物

6

反応物 3

HCID 7918Acetic AnhydrideHCID 114234-Bromo-2-methylanilineHCID 517045Sodium Acetate

生成物 1

HCID 222277N-(4-Bromo-2-methylphenyl)acetamide収率 99.9%

試薬・触媒・溶媒 2

HCID 1140Toluene溶媒HCID 8857Ethyl Acetate溶媒

反応条件

温度
85 °C

実験手順

Acetic anhydride (15.2 ml, 0.16 mol) was added dropwise to a stirred mixture of 4-bromo-2-methylaniline (10.0 g, 0.054 mol) and sodium acetate (2.52 g, 0.056 mol) in toluene (150 ml). Once the addition was complete the mixture was warmed to 85° C. and stirred for 40 minutes. The mixture was cooled to room temperature, diluted with ethyl acetate and washed with water. The organic solution was evaporated in vacuo, a further quantity of toluene was added and then the solvent was evaporated to give 4-bromo-2-methylacetanilide (12.3 g), as a colourless solid.

後処理

  1. additionOnce the addition
  2. temperatureThe mixture was cooled to room temperature
  3. washwashed with water
  4. customThe organic solution was evaporated in vacuo
  5. additiona further quantity of toluene was added
  6. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-469f6efd7aa8437e88791e175f260172
出典データセット
uspto-grants-2006_09
特許番号
US07112553B1

関連ノート

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