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Hydrochloric Acid → (6-Chloro-benzooxazol-2-yl)-(R)-1-pyrrolidin-3-ylmethyl-amine, hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | 2,6-Dichlorobenzoxazole | HCID 77175 | — |
| 反応物 | tert-Butyl (3S)-3-(aminomethyl)pyrrolidine-1-carboxylate | HCID 1514454 | — |
| 反応物 | (6-Chloro-benzooxazol-2-yl)-pyrrolidin-3-ylmethyl-amine | HCID 59178006 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | (6-Chloro-benzooxazol-2-yl)-(R)-1-pyrrolidin-3-ylmethyl-amine, hydrochloride | HCID 131728778 | — |
反応手順
In analogy to the procedure described for the synthesis of (6-Chloro-benzooxazol-2-yl)-pyrrolidin-3-ylmethyl-amine; hydrochloride (example 1, step 2) the title compound was prepared from (S)-3-aminomethyl-pyrrolidine-1-carboxylic acid tert-butyl ester and 2,6-dichloro-benzooxazole (commercially available) and subsequent cleavage of the tert-butyloxy carbonyl-protecting group through treatment with HCl in dioxane. MS (m/e): 252.2 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08207220B2 |
| 出典データセット | uspto-grants-2012_06 |
| ORD ID | ord-9d0366cd428f464a9f92da35da2bfa66 |
| 出典メモ | uspto-grants-2012_06 |