関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 3-Bromoaniline | HCID 11562 | — |
| 反応物 | 6-Chloropurine | HCID 5359277 | — |
| 触媒 | Hydrochloric Acid | HCID 313 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | N-(3-bromophenyl)-7H-purin-6-amine | HCID 9814520 | 102.8% |
反応手順
A mixture of 6-chloropurine (1.0 g, 6.47 mmol), 3-bromoaniline (0.78 mL, 7.12 mmol), and conc HCl (4 drops) in isopropanol (10 mL) is stirred at 80° C. for 5 h. Upon cooling, it precipitates. The solid is filtered and washed with isopropanol and air dried to yield N6 -(3-bromophenyl)adenine (1.93 g, 91%) as a light yellow solid. 1H NMR (DMSO) δ 11.38 (1H, s), 8.78 (1H, s), 8.75 (1H, s), 7.90 (1H, d, J=8.0 Hz), 7.38-7.34 (2H, m). ##STR15##
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US05654307 |
|---|
| 出典データセット | uspto-grants-1997_08 |
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| ORD ID | ord-13fb9e9504744c84bc4e335f6c995865 |
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| 出典メモ | uspto-grants-1997_08 |
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