Sodium hydride → 3-[2-(4,6-Dichloro-pyrimidin-5-ylamino)-pyrimidin-4-yl]-2-(4-fluoro-phenyl)-6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-one

関与物質

反応手順

To a solution of 5-amino-4,6-dichloropyrimidine (219 mg, 1.34 mmol) in THF (4 mL) is added NaH (0.07 g, 1.00 mmol). After stirring the mixture for 5 min at room temperature, 2-(4-fluorophenyl)-3-(2-methanesulfonyl-pyrimidin-4-yl)-6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-one, 5, (0.25 g, 0.67 mmol) is added to the reaction mixture. The reaction mixture is heated to reflux and stirred for 1 h. The mixture is diluted with aqueous saturated NH4Cl and extracted with twice with chloroform. The organic layers are combined, dried over MgSO4, and concentrated in vacuo to afford the crude product that is purified over silica (5% MeOH/chloroform) to provide the desired product as a yellow solid. 1H NMR (300 MHz, CDCl3) □ 8.77 (s, 1H), 8.35 (d, J=5.1 Hz, 1H), 7.35 (dd, J=9.0, 5.1 Hz, 1H), 7.10 (dd, J=8.7, 8.7 Hz, 2H), 6.71 (d, J=5.1 Hz, 1H), 4.25 (t, J=6.9 Hz, 2H), 4.12 (t, J=6.9 Hz, 2H), 2.74 (dddd, J=6.9, 6.9, 6.9, 6.9 Hz, 2H). ESI+ MS m/z (rel intensity) 458.1 (100, M++H). This compound corresponds to analog 441 from Table X.

情報源と証拠