関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1,2,3,4-Tetrahydroquinoline | HCID 69460 | — |
| 反応物 | 3-Fluorosulfonyl-6-methoxypyridazine | HCID 11030636 | — |
| 反応物 | Tetrahydroquinoline-1-sulfonyl-pyridazine | HCID 86589093 | — |
| 生成物 | 3-Methoxy-6-(tetrahydroquinoline-1-sulfonyl)-pyridazine | HCID 69049988 | 73% |
反応手順
3-Methoxy-6-(tetrahydroquinoline-1-sulfonyl-pyridazine. A mixture of 3-fluorosulfonyl-6-methoxypyridazine (2 mmol, 384 mg) and tetrahydroquinoline (4 mmol, 532 mg) was heated at 140° C. for two hours. The reaction mixture was cooled, extracted with EtOAc (20 mL), and the EtOAc extract was dried, filtered and evaporated to obtain 3-methoxy-6-(tetrahydroquinoline-1-sulfonyl)-pyridazine (73%, 451 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US06849629B2 |
|---|
| 出典データセット | uspto-grants-2005_02 |
|---|
| ORD ID | ord-676384e4c29d4a74a0018de6aa100369 |
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| 出典メモ | uspto-grants-2005_02 |
|---|
