化工社化工社 化学情報印刷レポート · 研究参考用
Methyl acetoacetate → 2-Methyl-1-[(R)-1-(tetrahydro-furan-2-yl)methyl]-5-(2-trifluoromethoxy-phenyl)-1H-pyrrole-3-carboxylic acid cyclohexylamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl acetoacetate | HCID 7757 | — |
| 反応物 | Cyclohexylamine | HCID 7965 | — |
| 反応物 | (R)-(-)-Tetrahydrofurfurylamine | HCID 2734124 | — |
| 反応物 | 2-(Trifluoromethoxy)phenacyl bromide | HCID 2778684 | — |
| 生成物 | 2-Methyl-1-[(R)-1-(tetrahydro-furan-2-yl)methyl]-5-(2-trifluoromethoxy-phenyl)-1H-pyrrole-3-carboxylic acid cyclohexylamide | HCID 11546877 | — |
反応手順
The title compound was synthesized in analogy to example 7, using 3-oxo-butyric acid methyl ester as compound of formula R, 2-bromo-1-[2-(trifluoromethoxy)phenyl]-ethanone as compound of formula S, (R)-tetrahydrofurfurylamine as R3—(CH2)m—NH2 and cyclohexylamine as R1R2NH, MS (ISP) 451.5 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07563910B2 |
| 出典データセット | uspto-grants-2009_07 |
| ORD ID | ord-19c79007c6d644dc8efceb46f516b0ed |
| 出典メモ | uspto-grants-2009_07 |