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Pyridine → HCID 20030580、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Oxalyl chloride | HCID 65578 | — |
| 反応物 | 1,1,2-Trichloroethanol | HCID 119427 | — |
| 反応物 | HCID 23690323 | HCID 23690323 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | HCID 20030580 | HCID 20030580 | 78% |
反応手順
Oxalyl chloride (2.8 g; 0.022 mol) is added to a suspension of compound 3 (4.1 g; 0.022 mol) in dichloromethane (50 cc). The mixture is heated under reflux until gas evolution ceases and then treated with a solution of trichloroethanol (3.3 g; 0.022 mol) and pyridine (3.5 g; 0.044 mol) in dichloromethane (30 cc). The mixture is then treated with water and then dried. After evaporation of the solvent and crystallization in pentane, 2,2,2-tri-chloroethyl 2-cyanonicotinate (4.55 g; m.p. 103° C.) is obtained (yield=78%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04851396 |
| 出典データセット | uspto-grants-1989_07 |
| ORD ID | ord-be80054748d5446480496c5b8647d737 |
| 出典メモ | uspto-grants-1989_07 |