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Benzyl Bromide → 4-Keto-1-[(phenylmethoxy)carbonyl]-L-proline benzyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzyl Bromide | HCID 7498 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | N-Carbobenzyloxy-4-keto-L-proline | HCID 11076282 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 4-Keto-1-[(phenylmethoxy)carbonyl]-L-proline benzyl ester | HCID 11624525 | 49% |
反応手順
5 g (0.02 mmol) of 4-keto-1-[(phenylmethoxy)carbonyl]-L-proline was dissolved in 50 ml dimethylformamide, 2.62 ml (0.022 mmol) of benzyl bromide and 3.59 g (0.026 mmol) of potassium carbonate were added. The reaction mixture was stirred for 1 hour followed by normal extractive work to give the title compound, 3.5 gm (49% yield), m.p. 55°-56° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04851514 |
| 出典データセット | uspto-grants-1989_07 |
| ORD ID | ord-9cce77e619164a6cbd81520207977231 |
| 出典メモ | uspto-grants-1989_07 |