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Chlorotrimethylsilane → Dimethyl 3,3'-(((3-formylphenyl)methylene)bis(sulfanediyl))dipropanoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chlorotrimethylsilane | HCID 6397 | — |
| 反応物 | Methyl 3-mercaptopropionate | HCID 18050 | — |
| 反応物 | Isophthalaldehyde | HCID 34777 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | Dimethyl 3,3'-(((3-formylphenyl)methylene)bis(sulfanediyl))dipropanoate | HCID 10021188 | 46.8% |
反応手順
To a solution of isophthalaldehyde (40 g, 0.3 mol.) in chloroform (400 mL) and methyl 3-mercaptopropanoate (68 mL, 0.6 mol.) was added dropwise trimethylsilyl chloride (48 mL, 0.38 mol.) over 30 min. The reaction mixture was stirred at R.T. for 2 hours. The reaction was quenched with 25% aq. NH4OAc, extracted with ethyl acetate dried and evaporated. Flash chromatography of the residue afforded 50 g of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04851409 |
| 出典データセット | uspto-grants-1989_07 |
| ORD ID | ord-be33ec09c8e1457ba75a4b286ca57168 |
| 出典メモ | uspto-grants-1989_07 |